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Trihexyphenidyl warnings

Tell your doctor if your condition persists or worsens. Monoamine oxidase inhibitors and tricyclic antidepressants possessing significant anticholinergic activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications. Such reactions tend to become less pronounced, and even to disappear, as treatment continues. Even before these reactions have remitted spontaneously, they may often be controlled by careful adjustment of dosage form, amount of drug, or interval between doses. If you are currently using any of these listed above, tell your doctor or pharmacist before starting this medication. Avoid taking MAO inhibitors within 2 weeks of starting or stopping this medication.

Store away from heat and direct light

If GI upset occurs, trihexyphenidyl may be taken with food. When the released salts reach the large intestine, they cause profuse stools or diarrhea because of their strong laxative effect. Devices and equipment, such as braces, casts, and splints. It should be noted that Phenelzine sulfate is not approved for use in treating any indications in the pediatric population. Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. Patients and their families or other caregivers should discuss all treatment choices with the healthcare provider, not just the use of antidepressants.

National Library of Medicine and Drugs

Phenelzine sulfate is extensively metabolized, primarily by oxidation via monoamine oxidase. After oral administration of 13C 6-Phenelzine, 73% of the administered dose was recovered in urine as phenylacetic acid and parahydroxyphenylacetic acid within 96 hours. Acetylation to N 2-acetylPhenelzine is a minor pathway. Trihexyphenidyl has been shown to cause some cognitive dysfunctions in the elderly, including confusion and memory impairment. Hemodialysis, peritoneal dialysis, and charcoal hemoperfusion may be of value in massive overdosage, but sufficient data are not available to recommend their routine use in these cases.

Trihexyphenidyl drug interactions

Food and Drug Administration for all antidepressants. Trihexyphenidyl hydrochloride occurs as a white or creamy-white, almost odorless, crystalline powder. It is very slightly soluble in ether and benzene, slightly soluble in water and soluble in methanol. It is not known whether trihexyphenidyl passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. Take the tablet, capsule, or liquid form by with or without food. Follow the directions for dosing on the label, or take as directed by your doctor. This medication may be taken with food or milk if upset occurs.



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But if the spasms are strong enough they can cause your eyelids to completely shut and then reopen. The anus "ring" or "circle" in Latin is made from the two circular bands of muscle that encircle the exit of the rectum. They are distinguished by their location and innervation. In other words, to prevent and treat hemorrhoidal disease you must have small, soft, regular stools and you must not strain. V" below the score. Available in bottles of 100, 500 and 1000. The dosage is based on your age, medical condition and response to therapy. Benztropine mesylate tablet US prescribing information. If you think you or anyone else has taken an overdose of this medicine, get emergency help at once. Taking an overdose of this medicine may lead to unconsciousness. Some signs of an overdose are clumsiness or unsteadiness; seizures; severe drowsiness; severe dryness of mouth, nose and throat; fast heartbeat; hallucinations seeing, hearing, or feeling things that are not there; mood or mental changes; shortness of breath or troubled breathing; trouble in sleeping; and unusual warmth, dryness, and flushing of skin. Trifluoperazine hydrochloride tablets, USP are effective for the short-term treatment of generalized non-psychotic anxiety. The dose of antidyskinetics will be different for different patients.



What are the possible side effects of trihexyphenidyl

Phenothiazines may lower the convulsive threshold; dosage adjustments of anticonvulsants may be necessary. Potentiation of anticonvulsant effects does not occur. However, it has been reported that phenothiazines may interfere with the metabolism of phenytoin and thus precipitate phenytoin toxicity. Chewable forms of this medication should be chewed thoroughly before swallowing. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Blood pressure should be observed frequently to detect evidence of any pressor response in all patients receiving Phenelzine sulfate. Therapy should be discontinued immediately upon the occurrence of palpitation or frequent headaches during therapy. Abrupt withdrawal of treatment for parkinsonism may result in of parkinsonism symptoms; therefore, abrupt withdrawal should be avoided. The list below is far from being comprehensive. The diagnostic evaluation of patients with this syndrome is complicated. It is sometimes possible to maintain the patient on a reduced ARTANE trihexyphenidyl dosage after the reactions have remained under control for several days. Instances have been reported in which these reactions have remained in for long periods after ARTANE trihexyphenidyl therapy was discontinued. Pharmaceuticals Inc. March, 2005. What should I discuss with my healthcare provider before taking trihexyphenidyl Artane? Hypermetabolic syndrome which may include, but is not limited to, hyperpyrexia, tachycardia, tachypnea, muscular rigidity, elevated CK levels, metabolic acidosis, hypoxia, coma and may resemble an overdose. It goes without saying, that all of these guides are interrelated, and all three steps are usually executed in parallel. Body temperature should be monitored closely. Intensive management of hyperpyrexia may be required. Maintenance of fluid and electrolyte balance is essential. Besides saving yourself a lot of grief, it may actually save your life. In many cases, the toilet bowl predicts your future with more certainty than a crystal ball. Although disturbances such as galactorrhea, amenorrhea, gynecomastia and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of antipsychotic drugs. Neither clinical nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusive at this time. Take this medication by with or without food with a full glass of water 8 ounces or 240 milliliters or as directed by your doctor. This medication may be taken with food or milk if upset occurs. zocor



Trihexyphenidyl adult dosage

Small or emaciated patients should always be started on the lower dosage. Enlarged hemorrhoids are a chronic but benign condition. These crises are characterized by some or all of the following symptoms: occipital headache which may radiate frontally, palpitation, neck stiffness or soreness, nausea, vomiting, sweating sometimes with fever and sometimes with cold, clammy skin dilated pupils, and photophobia. Either tachycardia or bradycardia may be present and can be associated with constricting chest pain. The management of NMS should include 1 immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. All patients undergoing treatment with Phenelzine sulfate should be closely followed for symptoms of postural hypotension. Hypotensive side effects have occurred in hypertensive as well as normotensive and hypotensive patients. Blood pressure usually returns to pretreatment levels rapidly when the drug is discontinued or the dosage is reduced. The presence of phenothiazines may produce false-positive phenylketonuria PKU test results. Dizziness, lightheadedness, or fainting may occur, especially when you get up from lying or sitting. Getting up slowly may help. If the problem continues or gets worse, check with your doctor. xdir.info butenafine



Reviews for trihexyphenidyl

If any of these effects persist or worsen, tell your doctor or promptly. Take this by with or without food, usually every 4 to 6 hours as needed or as directed by your doctor. This medication can be taken with food if upset occurs. Use a medication measuring device to carefully measure the prescribed dose. not use a household spoon. For best results, take with a full glass of water 8 ounces or 240 milliliters. Drink plenty of fluids when you use this medication unless otherwise directed by your doctor. In addition to adverse events seen in adults, the following adverse events have been reported in the literature in pediatric patients: hyperkinesia, psychosis, forgetfulness, weight loss, restlessness, chorea, and sleep alterations. Despite these considerable risks and lethal outcomes, straining isn't only considered normal, but is also encouraged by doctors who advise patients to strengthen their abdominal and pelvic muscles, so they can strain even harder. The symptoms are the result of the gradual degeneration of nerve cells in the portion of the midbrain that controls body movements. The first signs are likely to be barely noticeable -- a feeling of or stiffness in one limb, or a fine trembling of one hand when it is at rest. Eventually, the shaking tremor worsens and spreads, muscles become stiffer, movements slow down, and balance and coordination deteriorate. There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. Antipsychotic treatment itself, however, may suppress or partially suppress the signs and symptoms of the syndrome and thereby may possibly mask the underlying disease process. The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown. Your doctor should check your progress at regular visits, especially for the first few months you take this medicine. This will allow your dosage to be changed as necessary to meet your needs. Hemorrhoids are an intrinsic part of human anatomy. They protect the internal structures of the anal canal muscles, vessels, tissues from passing stools. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Sensitivity to the actions of parasympatholytic drugs may increase with age, particularly over the age of 60; therefore, elderly patients generally should be started on low doses of trihexyphenidyl and observed closely. Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient's presenting symptoms.



Trihexyphenidyl dosing information

If hemorrhoidal disease or anal fissures are left untreated, and their causes aren't eliminated, there is a distinct possibility of further anorectal complications such as fistulas, and abscesses, which in most cases require surgical intervention. The total daily intake of trihexyphenidyl is tolerated best if divided into 3 doses and taken at mealtimes. Since this medication may increase the susceptibility to heat stroke gastrointestinal GI problems, fever, heat intolerance use with caution during hot weather. Store in a tightly closed container at room temperature between 59-86 degrees F 15-30 degrees C away from light and moisture. not store in the bathroom. Do not freeze. Keep all medicines away from children and pets. Whatever you happen to have, all of these conditions are addressed in depth in the and guides. If you are affected by IBS, please also study the guide. Read the Medication Guide that comes with you or your family member's antidepressant medicine. This Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. Other therapies may also be needed, depending on specific needs. If hypotension occurs from parenteral or oral dosing, place patient in head-low position with legs raised. If a vasoconstrictor is required, norepinephrine bitartrate and phenylephrine hydrochloride are suitable. Other pressor agents, including epinephrine, should not be used as they may cause a paradoxical further lowering of blood pressure. Check the labels on all your medicines such as or -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. buy torsemide malarone



General information about trihexyphenidyl

External hemorrhoids cause pain, the sensation of which is related to inflammation of the skin that surrounds the thrombosed venal prolapse. Competitively inhibits acetylcholine or other cholinergic stimuli at autonomic effectors innervated by postganglionic nerves. Neuroleptic Malignant Syndrome NMS has been reported in association with antipsychotic drugs. At times, the bleeding may be profuse, but it usually stops when defecation is completed. In any event, it is best to see a doctor to rule out ulcers or tumors in close proximity to the rectum. These symptoms are seen in a significant number of hospitalized mental patients. They may be characterized by motor restlessness, be of the dystonic type, or they may resemble parkinsonism. United States. Women are twice as likely to get it as men. Dispense in a tight, light-resistant container with a child-resistant closure. Patients to be treated with trihexyphenidyl should have a gonioscope evaluation prior to initiation of therapy and close monitoring of intraocular pressures. The use of anticholinergic drugs may precipitate angle closure with an increase in intraocular pressure. If blurring of vision occurs during therapy, the possibility of narrow angle glaucoma should be considered. Blindness has been reported due to aggravation of narrow angle glaucoma. Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders. Anyone considering the use of Phenelzine sulfate or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Phenelzine sulfate is not approved for use in pediatric patients. Phenelzine sulfate is a potent inhibitor of monoamine oxidase. Because this enzyme is widely distributed throughout the body, diverse pharmacologic effects can be expected to occur. When they occur, such effects tend to be mild or moderate in severity see below often subside as treatment continues, and can be minimized by adjusting dosage; rarely is it necessary to institute counteracting measures or to discontinue Phenelzine sulfate. An encephalopathic syndrome characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN and FBS has occurred in a few patients treated with lithium plus an antipsychotic. In some instances, the syndrome was followed by irreversible brain damage. Because of a possible causal relationship between these events and the concomitant administration of lithium and antipsychotics, patients receiving such combined therapy should be monitored closely for early evidence of neurologic toxicity and treatment discontinued promptly if such signs appear. This encephalopathic syndrome may be similar to or the same as neuroleptic malignant syndrome NMS. Patients with arteriosclerosis or with a history of idiosyncrasy to other drugs may exhibit reactions of mental confusion, agitation, disturbed behavior, or nausea and vomiting. Such patients should be allowed to develop a tolerance through the initial administration of a small dose and gradual increase in dose until an effective level is reached. If a severe reaction should occur, administration of the drug should be discontinued for a few days and then resumed at a lower dosage. Psychiatric disturbances can result from indiscriminate use leading to overdosage to sustain continued euphoria. Store away from heat and direct light. Following the recommendations below, you can prevent your veins from getting dilated further, and your hemorrhoids from becoming larger and protruding even more. In most cases that's enough to stop pain, inflammation, bleeding, or prolapse, and keep it that way for as long as you guard your anus with the same vigilance you guard your credit rating. store glucophage tablets



What happens if I overdose Artane?

How should I take Artane trihexyphenidyl? Studies on effects in pregnancy have not been done in either humans or animals. However, antidyskinetics have not been shown to cause problems in humans. These conditions cause a rapid extraction of sodium chloride and fluids from feces. Dizziness, drowsiness, and confusion can increase the risk of falling. But several treatment options can make it less severe. If this phase becomes too troublesome, the symptoms can usually be controlled by a reduction of dosage or change of drug. Treatment with antiparkinsonism agents, benzodiazepines or propranolol may be helpful. If you take pramlintide with medicines that speed up the movement of food through your stomach, your pramlintide may not work as well. Ask your pharmacist about the safe use of those products. If your stools become larger than that, you need to strain to expel them. Xero-lube may relieve xerostomia that may accompany administration after meals.



What happens if I miss a dose Artane?

If you are using the liquid form, use a medication measuring device to carefully measure the prescribed dose. not use a household spoon. If your liquid form is a suspension, shake the bottle well before each dose. Edema of the glottis. Available as trihexyphenidyl hydrochloride; dosage expressed in terms of the salt. Treatment of acute overdose involves symptomatic and supportive therapy. Gastric lavage or other methods to limit absorption should be instituted. A small dose of diazepam or a short-acting barbiturate may be administered if CNS excitation is observed. Phenothiazines are contraindicated because the toxicity may be intensified due to their antimuscarinic action, causing coma. Respiratory support, artificial respiration or vasopressor agents may be necessary. Hyperpyrexia must be reversed, fluid volume replaced and acid-balance maintained. Urinary catheterization may be necessary. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. price of vistaril in south africa



What conditions does trihexyphenidyl treat

There was considerable variation in risk of suicidality among drugs, but a tendency toward an increase in the younger patients for almost all drugs studied. There were differences in absolute risk of suicidality across the different indications, with the highest incidence in MDD. The risk differences drug vs placebo however, were relatively stable within age strata and across indications. Ask your doctor or pharmacist about using this product safely. If you take pramlintide with anticholinergic or antispasmodic medicines, it may slow down the movement of food through your stomach too much and you may develop low blood sugar. Symptoms of low blood sugar include chills, cold sweat, dizziness, drowsiness, shaking, rapid heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger. Severe low blood sugar makes it hard to think clearly, drive a car, use heavy machinery, or do other risky activities where you could hurt yourself or others. If you don't wish to develop enlarged hemorrhoids or anal fissures in the near future, make sure your stools aren't larger than your index finger. This medicine may cause some people to have blurred vision or to become drowsy, dizzy, or less alert than they are normally. If the test is positive, and your pulse rate happens to be high, your blood pressure low, your appearance pale or you find that you're short of breath, fatigued or dizzy, you should call 911 at once. These are all symptoms of serious blood loss. The inflammation of the perianal skin caused by the residue of mucus and fecal matter, supplied by prolapsed tissue. Chromosomal aberrations in spermatocytes and abnormal sperm have been demonstrated in rodents treated with certain antipsychotics. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups. If trihexyphenidyl is replacing another antiparkisonian agent, increase trihexyphenidyl dose as needed while decreasing other drug dose until complete replacement is achieved. Newton's third law, of course: for every action there is an equal and opposite reaction. All patients should be warned that the following foods, beverages, and medications must be avoided while taking Phenelzine sulfate, and for two weeks after discontinuing use. Parkinson's disease is a form of parkinsonism. This is a more general term used to refer to the set of symptoms that is commonly associated with Parkinson's disease but sometimes stems from other causes. The distinction is important because some of these other causes may be treatable, while others do not respond to treatment or medication. naltrexone



Keep container tightly closed

To prevent a possible necrosis of strangulated hemorrhoidal tissue, an affected individual must seek immediate medical attention. When it isn't available, the prolapsed hemorrhoids should be returned back into the anal canal in order to relieve pain and prevent possible necrosis and infection. The affected area must be cleansed with warm water, which also helps to relax the anal sphincter. Petroleum jelly or non-medicated hemorrhoidal cream should be used to lubricate prolapsed hemorrhoids and the surrounding area before maneuvering them back inside the anal canal. Safety for the use of trifluoperazine hydrochloride during pregnancy has not been established. Therefore, it is not recommended that the drug be given to pregnant patients except when, in the judgment of the physician, it is essential. The potential benefits should clearly outweigh possible hazards. There are reported instances of prolonged jaundice, extrapyramidal signs, hyperreflexia or hyporeflexia in newborn infants whose mothers received phenothiazines. NOTE: Intracranial bleeding has been reported in association with the increase in blood pressure. Make sure laboratory personnel and all your doctors know you use this drug. Because of increased sedative effects, patients should be cautioned to avoid the use of alcohol or other CNS depressants while taking trihexyphenidyl. Neuroleptic Malignant Syndrome NMS has been reported in association with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmias.



Consult your pharmacist for further advice

However, rare cases of death associated with trihexyphenidyl overdosages taken in conjunction with other CNS-depressant agents have been reported or in patients with a compromised condition. Possible decreased intestinal mobility and paralytic ileus; use with caution in patients with obstructive diseases of the GI tract. Low levels of or in the may also increase your risk of QT prolongation. Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. Trihexyphenidyl HCl may be substituted, in whole or in part, for other parasympathetic inhibitors. The usual technique is partial substitution initially, with progressive reduction in the other medication as the dose of Trihexyphenidyl HCl is increased. Do not take more of it, do not take it more often, and do not take it for a longer period of time than your doctor ordered. To do so may increase the chance of side effects. If any of these effects persist or worsen, contact your doctor or promptly. The nerves of the anus and rectum are highly sensitive, and particularly so in children. Known hypersensitivity to trihexylphenidyl or any ingredient in the formulation. Concurrent use of alcohol or other CNS depressants with trihexyphenidyl may cause increased sedative effects. Trihexyphenidyl should be administered with caution in hot weather, especially when given concomitantly with other atropine-like drugs to the chronically ill, alcoholics, those who have central nervous system disease, or those who do manual labor in a hot environment. Anhidrosis may occur more readily when some disturbance of sweating already exists. If there is evidence of anhidrosis, the possibility of hyperthermia should be considered. Dosage should be decreased so that the ability to maintain body heat equilibrium via perspiration is not impaired. Severe anhidrosis and fatal hyperthermia have occurred with the use of anticholinergics under the conditions described above. antabuse



How to use trihexyphenidyl

Doctors and patients alike universally refer to hemorrhoidal disease as hemorrhoids, which is technically incorrect. That's why this chapter refers to hemorrhoidal disease throughout, rather than hemorrhoids. Care should be taken to administer this drug slowly in order to avoid producing an excessive hypotensive effect. Fever should be managed by means of external cooling. In children, excitement may occur first, and may be followed by loss of coordination, drowsiness, loss of consciousness, seizures. Possible mental confusion, disorientation, agitation, hallucinations, and psychotic-like symptoms. Signs and symptoms of overdosage may include, alone or in combination, any of the following: drowsiness, dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucinations, trismus, opisthotonus, rigidity, convulsions, and coma; rapid and irregular pulse, hypertension, hypotension, and vascular collapse; precordial pain, respiratory depression and failure, hyperpyrexia, diaphoresis, and cool, clammy skin.



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Common side effects of trihexyphenidyl


Trihexyphenidyl overdose

Trifluoperazine Hydrochloride Tablets, USP and have their WBC followed until recovery. The term "anal canal c" refers to the passageway formed by the opening of both sphincters, usually during bowel movement. What are conjugated billary salts? For quick reference, the following antidyskinetics are numbered to match the corresponding brand names. Pearl River, NY 10965.

Side effects of trihexyphenidyl

If you are using the liquid form of this medication, measure your dose with a special measuring spoon or device. Do not use a household spoon because it may not provide the correct dose. Your dosage is based on your age, medical condition, and response to therapy. Do not increase your dose or take this medication more often than recommended by your doctor or the package instructions without your doctor's approval. Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same times each day. Hemorrhoidal bleedings are distinguished by crimson streaks of fresh blood on the passing stools. The stool itself doesn't change color, because there was no prior contact between feces and the laceration.

How to take trihexyphenidyl

The pooled analyses of placebo-controlled trials in children and adolescents with MDD, obsessive compulsive disorder OCD or other psychiatric disorders included a total of 24 short-term trials of 9 antidepressant drugs in over 4400 patients. Surgery can also relieve the pressure of the artery on your facial nerve that causes a hemifacial spasm. The effectiveness of trifluoperazine hydrochloride tablets as a treatment for non-psychotic anxiety was established in a 4-week clinical multicenter study of outpatients with generalized anxiety disorder DSM-III.

Before taking trihexyphenidyl

To date, fatal progressive necrotizing hepatocellular damage has been reported in very few patients. Reversible jaundice. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Your doctor may need to adjust your dose, depending on your condition. The conjugated billiary salts form in the gallbladder from bile, and are the precursors of gallbladder stones. Fat-free or low-fat diets and obstruction of the duct that connects the gallbladder to the duodenum contribute to formation of gallstones. The obstruction itself may be caused by salts, stones, inflammation, or a combination of all three.

Rarely, abnormal drug-seeking behavior addiction is possible with this medication. Do not increase your dose, take it more frequently, or take it for a longer time than prescribed. Properly stop the medication when so directed. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased. Phenelzine sulfate may cause excessive stimulation in schizophrenic patients; in manic-depressive states it may result in a swing from a depressive to a manic phase. Do not start, stop, or change the dosage of any medicine before checking with them first. Working with others involved with your child's care, understanding your child's needs and rights, and taking care of yourself and other family members are all important parts of treatment.

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